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Welcome to the EKIBUBBA LIFT - The Travel Blog, Delhi..Ekibubba lift was started by Fadheepal and Mehul (a.k.a. Fadheepal). We have been in this travel industry for a very long time and we love to share our travel experiences and review our travel destinations. We hope you enjoy your stay on our travel blog. :)A Pilot Study of the Effects of Bupropion on Resting-State Functional Connectivity in Elderly Patients With Major Depressive Disorder.
Background: Neuroimaging studies have demonstrated a decreased functional connectivity in the default mode network in elderly patients with major depressive disorder (MDD) and that antidepressants increase the resting-state functional connectivity. However, whether older individuals with MDD respond differently to antidepressants remains unclear.Methods: In a single-center, single-group, randomized, double-blinded, placebo-controlled study, elderly patients with MDD who were older than 65 years were administered with flexible-dose (150 mg/day to 300 mg/day) of bupropion, which is the most frequently prescribed antidepressant in this population. Resting-state functional connectivity was assessed with the CONN toolbox in 17 patients with MDD using fMRI before and after 8 weeks of treatment.Results: Compared with the placebo, bupropion did not increase the overall resting-state functional connectivity or the task-related functional connectivity, but it showed a trend of increasing the coupling between the right inferior frontal gyrus and the right middle frontal gyrus in the MDD group (P =.068).Conclusion: These preliminary findings suggest that bupropion may have a selective effect on the coupling between the frontal cortices in elderly patients with MDD. ClinicalTrials.gov identifier: NCT02743286.Ventricular refractoriness and conduction are integral components of normal sinoatrial and atrioventricular conduction. Ventricular refractoriness is due to prolongation of the ventricular action potential. Prolongation of the ventricular action potential is brought about by depolarization of the muscle membrane during early parts of the action potential. While the mechanism underlying prolongation of the action potential is not fully understood, it is known that, in some cases, it is due to the accumulation of sodium ions in the muscle membrane. The electrical activity of the ventricular muscle is also modulated by the in 01e38acffe
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